摘要
干细胞具有分化、再生能力,通过体外扩增和体内移植,可以治疗各种组织坏损和退化性疾病(如心脑血管疾病、脑脊髓外伤和糖尿病等),具有极大的应用前景,是目前国际、国内的研究热点。利用核素显像、磁共振成像和光成像等分子影像技术,通过体外直接标记、报告基因或功能显示等追踪策略,可以显示干细胞在活体内的分布和变化,明确其最终归宿和产生的功能。合理选择这些分子影像技术和追踪策略,或通过互补结合,将有助于阐明干细胞在活体内的作用机制和相关的影响因素,指导临床干细胞治疗抉择和疗效评估。
Stem cell therapy is a hot topic of current medical research. By ex vivo expansion and in vivo transplantation, stem cells can be taken as a regenerative ＂pharmaceutical＂, and hold promise to treat various diseases with tissue damage or cell loss, such as cardiovascular disease, diabetes mellitus, and some brain diseases. Molecular imaging, including radionuclide imaging, magnetic resonance imaging, and optical imaging, has been playing an important role in monitoring and evaluating stem cell therapy. The tracking strategies, such as direct labeling of stem cells, reporter gene techniques, and functional characterization of targets, can help to reveal the distribution, homing, and destiny of stem cells in vivo, and evaluate the resumed function of target organs or tissues. In this article, we reviewed the new advances of the field, and discussed the advantages and weakness of related techniques.
出处
《现代仪器》
2007年第4期6-8,5,共4页
Modern Instruments
关键词
干细胞
分子影像
核素显像
磁共振成像
光成像
Stem cell In vivo tracking Radionuclide imaging Magnetic resonance imaging Optical imaging
