摘要
目的为了研究乳腺癌中的HPV16感染对hTERT蛋白表达的影响。方法检测了人乳头状瘤病毒HPV16和人端粒酶逆转录酶(hTERT)在乳腺癌中的表达。应用免疫组化SP法共检测了52例乳腺癌和16例乳腺良性瘤HPV16和hTERT蛋白的表达。结果表明HPV16和hTERT蛋白在乳腺癌组的阳性表达率均显著高于乳腺良性瘤组。统计分析表明,hTERT蛋白表达阳性率与HPV感染率密切相关(P<0.05)。结论HPV16感染参与了乳腺癌的发生,其致癌机制可能是通过某种途径引起hTERT蛋白表达增加而导致乳腺癌的发生。
To investigate the affection of infection of human papillomavirus on expression of hTERT （human telomerase reverse transeiptase） in breast cancer, we detected the expression of HPV - 16 and hTERT. Fifty - two samples of breast cancer and sixteen samples of benign breast tumor were assayed using immunohistoehemieal SP method for detection of HPV - 16 and hTERT protein expression level. The expression of HPV - 16 and hTERT was higher than that of the benigh breast tumor group. Analysis showed that the expression of hTERT was obviously correlated with the infection of HPV16 in breast cancer（ P 〈 0.05）. HPV might play an important role in carcinogenesis of breast cancer in Harbin. Its possible mechanism was as follows： Infection of HPV induced the activation of hTERT by an unknown route. This might promote the generation of breast cancer.
出处
《黑龙江医学》
2007年第7期490-492,共3页
Heilongjiang Medical Journal
基金
黑龙江省农垦总局指导项目
