摘要
目的为了研究乳腺癌中的HPV16感染对p53和hTERT蛋白表达的影响,检测了人乳头状瘤病毒HPV16和抑癌基因p53蛋白及人端粒酶逆转录酶hTERT在乳腺癌的表达。方法应用免疫组化S-P法共检测了52例乳腺癌和16例乳腺良性瘤HPV16和p53及hTERT蛋白的表达。结果表明HPV16和p53及hTERT蛋白在乳腺癌组的阳性表达率均显著高于乳腺良性瘤组。统计分析表明,p53蛋白和hTERT蛋白表达阳性率与HPV感染率密切相关(P＜0．05)。结论HPV16感染参与了乳腺癌的发生,其致癌机制可能是通过突变型p53蛋白表达上调,引起hTERT蛋白表达增加而导致乳腺癌的发生。
To investigate the affection of human infection papillomavirus on expression of protein p53 and hTERT （human telomerase reverse transciptase） in breast cancer, we detected the expression of HPV-16,p53 and hTERT. Fifty-two samples of breast cancer and sixteen samples of benign breast tumor were assayed using immunohistochemical SP method for detection of HPV- 16, p53 and hTERT protein expression. The expression of HPV-16,p53 and hTERT was higher than that of the benign breast tumor group.Analysis showed that the expression of p53 and hTERT was obviously correlated with the infection o f HPV16 in breast cancer （ P 〈 0.05）. HPV might play an important role in carcinogenesis of breast cancer in Harbin. Its possible mechanism was as follows： the mutation of wild type p53 induced by HPV through unknown route promoted the expression of hTERT which induced the development of mammary cancer.
出处
《实用肿瘤学杂志》
CAS
2007年第3期221-223,共3页
Practical Oncology Journal
基金
黑龙江省农垦总局指导项目
关键词
乳腺癌
HPV16
P53
HTERT
Breast cancer
Human papillomavirus
p53
Human telomerase reverse transciptase
