摘要
目的观察CA15-3和CEA联合检测在乳腺癌术后监测中的价值。方法120例乳腺癌术后患者,空腹取静脉血,分别采用免疫放射分析法(IRMA)和放射免疫分析法(RIA)测定CA 15-3和CEA。结果①乳腺癌术后无复发转移100例,其中CA 15-3增高4例、CEA增高3例,阳性率分别为4.0%、3.0%。复发转移20例,其中CA 15-3增高15例、CEA增高11例,敏感度分别为75.0%、55.0%。CA15-3和CEA两者均异常,在无复发转移组为0,复发转移组6例,其敏感度为30.0%,联检两者之一阳性14例,其敏感度为70.0%,联检与单独检测CA 15-3比较无显著性差异(P>0.05)。②复发或转移乳腺癌患者CA 15-3和CEA水平显著高于无复发或无转移乳腺癌患者(P<0.01)。结论CA 15-3和CEA的检测可作为乳腺癌术后随访的重要指标,对预测复发转移具有重要意义。
Objective To investigate the significance of combined detection of CA 15-3 and CEA in the postoperative patients with breast cancer. Methods The concentratitons of CA 15-3 and CEA were respectively detected by IRMA and RIA in blood. Results （1） The levels of CA 15-3 in 4 cases and CEA in 3 cases were increased in the 100 postoperative breast cancer patients without recurrence and metastasis,and the positive rate is 4.0% and 3.0% respectively. In the 20 cases with recurrence and metastasis, 15 patients were measured with higher CA 15-3 and 11 patients with higher CEA,which the sensitivity is 75.0% and 55.0% respectively. 14 positive patients were detected by either of the methods,which the sensitivity is 70.0%. Combined detection had no significant difference compared with CA 15-3 alone. No case in patients without recurrence and metastasis and 6 eases in patients with metastasis and recttrrence were detected for both CA 15-3 and CEA concurrent abnormality, its sensitivity is 30.0%. （2）Tbe level of CA 15-3 or CEA is significantly higher in the breast cancer patients with metastasis and recurrence than that in those metastasis and recurrence. Conclusion The detection of CA 15-3 and/or CEA can be an important index for the follow-up to the postoperative breast cancer, and is important for predicting the recurrence and metastasis of breast cancer.
出处
《白求恩军医学院学报》
2007年第4期212-213,共2页
Journal of Bethune Military Medical College
