摘要
目的 观察CA15 3和CEA联合检测在乳腺癌术后随访中的价值。方法 空腹取静脉血分别采用免疫放射分析法 (IRMA)和放射免疫法 (RIA)测定CA15 3和CEA。结果 ①乳腺癌术后无复发转移12 7例 ,其中CA15 3增高 3例、CEA增高 2例 ,阳性率分别为 2 4 %、1 6 %。复发转移者 18例 ,其中CA15 3增高 15例、CEA增高 8例 ,其敏感度分别为 83 3%、4 4 4 % ,特异度分别为 97 6 %、98 4 %。CA15 3和CEA两者均异常在无复发转移组为 0 ,复发转移组 6例 ,其敏感度为 33 3% ,特异度为 10 0 %。联检两者之一阳性 16例 ,其敏感度为 88 9% ,特异度为 96 1%。经 χ2 检验 ,与单独检测CA15 3比较无显著性差异 (P >0 .0 5 )。②复发或转移乳腺癌患者CA15 3和CEA水平显著高于无复发或转移乳腺癌患者 (P <0 .0 1)。结论 CA15 3和CEA的检测可作为乳腺癌术后随访的重要指标 ,单独检测CA15 3和 或联合CEA对预测复发转移具有重要意义。
Objective Investigating the follow-up value of combined measure of CA15 3 and CEA.Methods CA15 3 and CEA were respectively detected by IRMA and radioimmunoassay(RIA) with the fasting vein blood.Results ①The value of CA15 3 in 3 cases and CEA in 2 cases increased of the total 127 postoperative breast cancer patients without recurrence or metastais, the positive rates were 2.4% and 1.6% respectively. In the 18 cases with recurrence and metastasis, 15 patients were measured with higher CA15 3?CEA, the sensitivity were 83.3%?44.4% and specificity were 97.6%?98.4%; 16 positive patients were detected by eigher of the methods, the sensitivity were 88.9% and the specificity was 96.1%. There was no significant difference compared with detecting CA15 3 alone by x 2 analysis. 0 in patients without recurrence or metastasis and 6 in patients with metastasis and recurrence were detected abnormal CA15 3 and CEA concurrently, sensitivity and specificity were 33.3% and 100%. ②The level of CA15 3 or CEA was significant higher in the breast cancer patients with metastasis and recurrence than those without metastasis and recurrence.Conclusion The detection of CA15 3 and/or CEA can be an important index for the follow-up to the postoperative breast cancer, it is important for the detction of CA15 3 and /or CEA to predict the recurrence and metastasis of breast cancer.
出处
《陕西肿瘤医学》
2002年第3期166-167,共2页
ShanXi Oncology Medicine
