摘要
目的了解我院2004至2005年流感嗜血杆菌的分离率、产酶率,并对其耐药性进行分析,指导临床合理用药控制嗜血杆菌的流行。方法对1695份痰及咽拭子标本进行嗜血杆菌分离培养、鉴定,并用头孢硝噻吩纸片法进行β-内酰胺酶测定,采用琼脂扩散法进行药敏试验。结果共分离出226株嗜血杆菌,其中流感嗜血杆菌52株,副流感嗜血杆菌174株。产β-内酰胺酶42株,对氨苄西林、复方新诺明、环丙沙星的耐药率分别为22.1%、74.3%和57.5%。而对阿莫西林/棒酸、阿奇霉素、头孢噻肟、头孢呋辛钠、亚胺培南、利福平、氨曲南的耐药率均低于10%。结论我院呼吸道嗜血杆菌感染以副流感嗜血杆菌为主,临床上治疗嗜血杆菌感染最有效的药物是头孢噻肟。
Objectives To investigate the isolation rate ,enzyme-producing rate and drug resistance of Haemophilus infuenzae and Haemophilus prarinfluenzae during 2004 - 2005 in our hospital And to provide a resistance analysis for the guidance of treatment of Haemophilus species infection. Methods Haemophilus from 1695 sputa and throat swabs were isolated and identifed. The β-lactamases producing rate was examined by nitrocefin. Drug resistance of Haemophibus was examined by K-B method. Results Of 226 Haemophilus species, 52 were Haemophilus infulenzae, and 174 were Haemophilus parainfulenzae. And 42 were β-lactamases producing. The resistance rate of Ampicillin,Trimethoprim/Sulfa, Ciprofloxacin were 22.1%, 74.3 % and 57.5%. But the resistance rate of Amoxicillin/Clavulanic, Azithromycin, Cefotaxime, Cefuroxime sodium, Imipem, Rifampin,Aztreonam were under 10%. Conclusions Haemophilus parainfluenzae was the main infection in person with respiratory tract infection in our hospital. Cefotaxine was the most effective antibiotics for Hsemophilus species infection.
出处
《中国微生态学杂志》
CAS
CSCD
2007年第1期78-79,共2页
Chinese Journal of Microecology
关键词
呼吸道感染
嗜血杆菌
耐药性
Β-内酰胺酶
Respiratory tract infection
Haemophilus
Drug resistance
β-lactamase
