摘要
目的了解本地区呼吸道感染中嗜血杆菌的感染情况及耐药性,以便有效地指导临床合理用药。方法对760例呼吸道感染患者的呼吸道分泌物进行嗜血杆菌的培养及鉴定,以K-B法进行药物敏感性试验。β-内酰胺酶试验采用Nitrocefin纸片法。结果共分离出嗜血杆菌130株,分离率为17.11%(130/760),其中流感嗜血杆菌85株,占65.38%(85/130),副流感嗜血杆菌45株,占34.62%(45/130)。药敏结果显示两种嗜血杆菌的耐药性没有明显差异(P>0.05),阿莫西林/克拉维酸、阿齐霉素、亚胺培南、头孢他啶的耐药性均较低,小于5%,是治疗的首选药物。β-内酰胺酶阳性率为29.23%。结论本地区呼吸道感染嗜血杆菌的耐药形势严峻,产β-内酰胺酶阳性率较高,应引起重视。
【Objective】To investigate the infectious state and drug resistance of Haemophilus in acute respiratory tract infection so as to instruct the rational use of antibiotics.【Methods】Haemophilus was isolated from 760 patients with respiratory tract infection and its drug resistance was tested by K-B methods. Nitrocefin slip test was applied to detect β-lactamase. 【Results】A total of 130 Haemophilus strains were isolated from 760 specimens, the isolation rate was 17.11 %. Among which there were 85 strains of Haemophilus influenzae（85/130, 65.38 %）and 45 strains of Haemophilus parainfluenzae （45/130, 34.62 %）. Amoxicillin/clavulanic acid, azithromycin, imipenem and ceftazidime had better antibiotic action and the average drug resistance was lower than 5 %. The drug resistance of the two kinds of Haemophilus was in accordance with each other （P 0.05）. The β-lactamase positive rate was 29.23 %.【Conclusion】Importance must be attached to the multiple drug resistance and high β-lactamase positive rate of Haemophilus isolated from respiratory tract.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第4期602-604,共3页
China Journal of Modern Medicine
关键词
呼吸道感染
嗜血杆菌
耐药性
Β-内酰胺酶
respiratory tract infection
Haemophilus
drug resistance
β-lactamase
