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Paxillin及其在肿瘤转移中的作用 被引量：12

Paxillin and its role in Tumor Metastasis
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摘要 Paxillin是一种主要定位于粘着斑且与细胞黏附相关的磷酸蛋白。通过磷酸化调节,paxillin参与细胞的黏附和迁移。已发现其与多种肿瘤的恶性生物学特征有关。本文就paxillin的结构特点及其在肿瘤转移中的作用进行综述。 Paxillin is a cell adhesion related phosphoric protein,which mainly located on adhesion plaque. Regulated by Phosphorylation, paxillin takes part in cell adhesion and migration. Many study showed that it was related to many malignant biological characters of tumor. The present review focused on the evidence of the structure of paxillin and the role it plays in tumor metastasis.
作者 许文集 陈玉丽 庄则豪
机构地区 福建医科大学附属第二医院消化内科 福建医科大学附属第一医院消化内科
出处 《医学综述》 2007年第3期198-200,共3页 Medical Recapitulate
关键词 肿瘤转移 桩蛋白 细胞黏附 Tumor metastasis Paxillin Adhesion
分类号 R730.6 [医药卫生—肿瘤]
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  • 1Zhao-You Tang Liver Cancer Institute & Zhongshan Hospital of Fudan University Professor of Surgery Chairman.Liver Cancer Institute of Fudan University(previous Liver Cancer Institute of Shanghai Medical University)136 Yixueyuan Road,Zhongshan Hospital,Shanghai 200032,China..Hepatocellular Carcinoma-Cause,Treatment and Metastasis[J].World Journal of Gastroenterology,2001,7(4):445-454. 被引量：214
  • 2同济医科大学病理教研室 中山医科大学病理学教研室.外科病理学（上册）[M].湖北科学技术出版社,1999,11.221-222,600-625.
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  • 7Nakamura K, Yano H, Uchida H, et al. Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and Factln organization in motile cells. J Biol Chem, 2000; 275(35):27155.
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医学综述
2007年 第3期

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