摘要
目的:研究葡萄糖调节蛋白94(G rp-94)、桩蛋白(Paxillin)、P-选择素(P-selectin)在子宫内膜癌组织中的表达及意义。方法:免疫组化S-P法检测子宫内膜癌患者50例,观察肿瘤相关基因G rp-94、Paxillin、P-选择素的表达与子宫内膜癌发生、浸润及转移的关系。结果:①50例子宫内膜癌组织中,G rp-94、Paxillin、P-选择素阳性表达率分别为68.0%、54.0%和60.0%。②G rp-94在子宫内膜癌不同组织学分级中的表达差异无统计学意义(P>0.05),但从直观看随着分化程度的降低,G rp-94的阳性表达增高。Paxillin、P-选择素在不同组织学分级中的表达差异均有统计学意义(P<0.05)。三者在有、无淋巴结转移的子宫内膜癌患者中的表达差异均有统计学意义(P<0.05)。结论:G rp-94、Paxillin、P-选择素在子宫内膜癌的发生发展过程中关系密切,与手术病理分期关系不密切,可成为预测子宫内膜癌转移及预后的标志物。
Objective：To study the expression and the clinical pathology significance of Grp-94,Paxillin,the P-selectin in the endometrium cancer tissues.Methods：50 patients with endometrium cancer were tested by immunohistochemistry S-P technique in tumor related gene Grp-94,Paxillin,the P-selectin.The relationship among the expression and occurrence and the infiltration and the shift were analyzed.Results： ① In 50 endometrium cancer tissurs,the positive rate of Grp-94,Paxillin,p-selectin was respectively 68.0 %,54.0%,60.0%.②There was no significant difference in the expression of Grp-94,but from the perspective of visual,the positive expression of Grp-94 increased with the reduction of degree of differentiation.There were significant differences in the expression of Paxillin and p-selectin in different histological classification（P0.05）.In addition,there ass the difference with lymphnode metastas in carcinoma tissues without lymphnode metastasis（P0.05）.Conclusion：It is suggested that Grp-94,Paxillin,the P-selectin have a close relationship with the endometrium metastasis and the prognosis and no closed relation with surgery pathology stages.
出处
《中国妇幼保健》
CAS
北大核心
2011年第14期2190-2192,共3页
Maternal and Child Health Care of China
