摘要
目的研究食管鳞状细胞癌神经组织浸润与临床病理学指标、预后及EMMPRIN蛋白的关系。方法复习159例ESCC组织常规切片,并用免疫组织化学染色检测85例ESCC组织EMMRIN的表达,分析ESCC的神经组织浸润与性别、年龄、组织学分化程度、肿瘤浸润深度、淋巴结转移、临床分期、预后等生物学行为和EMMPRIN的关系。结果 159例ESCC神经组织浸润的发生率为42％,85例ESCC EMMPRIN的阳性率为80％。神经组织浸润与肿瘤浸润深度、淋巴结转移和临床分期均呈正相关(P分别为0．013、0．000和0．004,r分别为0．29、0．41和0．30),与性别、组织学分化程度和预后均无关(P＞0．05)。85例ESCC EMMPRIN的表达与神经组织浸润无关(P＞0．05)。结论 ESCC的神经组织浸润与肿瘤的浸润深度、淋巴结转移和临床分期等生物学行为有密切关系,提示发生神经组织浸润的ESCC具有较强的浸润和转移能力。
Objective To investigate the relationship among nervous tissue infiltration of squamous cellular carcinoma of esophagus （ESCC） and clinical/pathological indexes, prognosis and expression of matrix metalloproteinase inducer （EMMPRIN） protein. Methods 159 ESCC patients were reviewed and 85 of them were detected with immunohistochemistry for observing the expression of EMMPRIN protein and the relationship of ESCC of nervous tissue infiltration to sexes, age, degree of histochemical differentiation, depth of infiltration of carcinoma, lymphoid metastasis , prognosis and EMMPPdN was analyzed. Results The occurrence rate of 159 ESCC patients was 42%. The occurrence rate of nervous tissue infiltration was positive to the depth of carcinoma infiltration, lymphoid metastasis, clinical differentiation （ with a P = 0.013, 0.00 and 0.004, respectively ）. While the occurrence rate of nervous tissue infiltration was inconsistent with sex, degree of histological differentiation and prognosis （ P 〉 0.05）. The Express of EMMPRIN in85 ESCC patients was inconsistent with nervous tissue infiltration （ P 〉 0.05）. Conclusion The nervous tissue infiltration of ESCC is closely relevant with the biological activities of depth of carcinoma infiltration, lymphoid metastasis and clinical differentiation, suggesting that the occurrence of nervous tissue infiltration of ESCC possesses relatively strong capacity of infiltration and metastasis.
出处
《中国热带医学》
CAS
2006年第3期439-440,424,共3页
China Tropical Medicine
基金
广东省重点攻关项目(编号:2003830104)
