摘要
目的评价食管癌FDG PET／CT检测的标准摄取值（SUV）与肿瘤细胞葡萄糖转运蛋白1（Glutl）和Ki-67抗原表达的相关性。方法对56例食管癌患者，术前行FDGPET／CT检测，术后应用免疫组织化学S-P法对癌组织进行Glutl与Ki-67抗原表达的检测。结果（1）56例食管癌组织中Glutl与Ki-67均呈阳性表达。Glutl和Ki-67的表达量与病理分级及临床分期呈正相关，随着分化程度的降低和临床分期增高，Glutl与Ki-67的表达量增加。（2）56例患者PET／CT显像食管部位均有异常放射性浓聚灶，经病理检查证实，56处食管浓聚灶均为食管癌原发灶。原发灶SUV均〉2．5。随着分化程度的降低与临床分期的增加，SUV值有逐渐增大的趋势。（3）肿瘤组织内Glutl和Ki-67的表达与SUV均有相关性，Glutl与Ki-67表达高的食管癌组织有高的^18F—FDG摄取。结论Glutl在食管癌组织中广泛表达，SUV可间接评价食管癌细胞的增殖能力。
Objective To evaluate the correlation between standardized uptake valus （SUV） of ^18F- fluorodeoxyglucose （^18F-FDG） of tumor at PET/CT examination and the expression of glucose transporter-1 （ Glutl ） and Ki-67 in esophageal cancer. Methods 56 patients with esophageal cancer were evaluated with ^18F-FDG PET/CT examination before operation. The expression of Glutl and Ki-67 antigen in the tumor tissues was detected by immunohistochemistry after operation. Results （ 1 ） Positive rate of Glutl and Ki-67 expression in esophageal cancer tissues was 100%, respectively. There was a positive correlation between the expression of Glutl and Ki-67 and the clinical stages and differentiation of the tumor. The more the tumor and the clinical stages were advanced and the lower was the tumor differentiation, the more Glutl and Ki-67 were expressed. （2）There were abnormal radioactive high uptake regions on PET/CT imaging of esophagus in the 56 patients, which were confirmed by pathology as the primary carcinoma. The SUV was higher than 2.5. There was a gradually increasing tendency in SUV along with the lowering of the tumor differentiation and the advance of clinical stages. （3）There was a correlation between the expression of Glutl, Ki-67 and the SUV, the more Glutl and Ki-67 were expressed, the higher the SUV of tumor ^18F-FDG at PET/CT examination was in esophageal tumor tissues. Conclusion There is a widespread expression of Glutl in esophageal cancer tissues, and the SUV may be used to indirectly evaluate the proliferative capacity of esophageal cancer.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2007年第1期30-33,共4页
Chinese Journal of Oncology
基金
山东省卫生厅医药卫生科技发展计划资助项目（2005HW137）
