摘要
目的 探讨非小细胞肺癌 (NSCLC)标准摄取值 (SUV)与肿瘤增殖细胞核抗原 (PCNA)表达的关系。方法 3 0例经术后组织病理检查证实为NSCLC患者于术前行全身1 8F 脱氧葡萄糖 (FDG)PET显像 ,测定SUV ,随访预后 ;手术获得肿瘤标本经常规石蜡切片 ,用免疫组织化学技术检测肿瘤组织PCNA表达 ,计算肿瘤细胞PCNA表达阳性百分数 (即PCNA指数 ) ,取肿瘤周围正常肺组织作对照。结果 正常肺组织肺泡细胞PCNA指数均小于 5 % ,肺癌细胞PCNA指数为 (4 9.49± 2 1.2 4) % ,且PCNA指数与SUV之间具有明显的相关性 (r =0 .82 6,P <0 .0 1) ,PCNA表达高的肺癌细胞有高FDG摄取趋势 ;随SUV及PCNA指数的升高 ,肺癌出现复发或转移的几率升高 ,且与未出现复发或转移者之间差异有显著性 (P <0 .0 1)。结论 SUV可间接评价NSCLC细胞的增殖能力 。
Objective To investigate whether 18F-fluorodeoxyglucose (FDG) uptake within the primary tumor correlates with cell proliferation in non-small cell lung cancer. Methods Thirty patients with non-small cell lung cancer were examined with FDG PET within 20 d prior to surgery. For semiquantitative analysis, standardized uptake value (SUV) was calculated. The expression of proliferating cell nuclear antigen (PCNA) was immunohistochemically assessed and the normal lung tissue around the tumor was regarded as the control. We also followed-up the outcome of every patient of the study group. Results PCNA expression (PCNA labeling index )of alveolus cell in normal lung tissue was lower than 5%, and was (49.49±21.24)% in the lung cancer lesion. FDG SUV correlated significantly with PCNA labeling index (r=0.826, P<0.01). The SUV and PCNA labeling index were significantly different between the patients with and without recurrence and (or) metastasis (P<0.01). Conclusions FDG uptake relates to cell proliferation in non-small cell lung cancer. As a non-invasive imaging technique, the SUV of FDG in 18F-FDG PET imaging may be valuable in prognostic prediction.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2003年第1期14-16,W001,共4页
Chinese Journal of Nuclear Medicine
