摘要
目的:探讨食管癌组织MMP-2表达与肿瘤细胞增殖以及肿瘤侵袭、转移的关系.方法:用免疫组织化学S-P法,检测75例食管癌、30例对照组（食管切缘正常组织）MMP-2、Ki67的表达，分析MMP-2表达与临床病理因素的关系.结果:食管癌MMP-2和Ki67表达率分别为82.7%和78.7%(均高于正常食管组织,(P<0.005),两者均表达51例,符合率为74.7%,两者差异无显著性(P＞0.05);MMP-2表达与癌细胞的血管侵袭、侵袭深度、食管旁淋巴结转移有一定的关系(P<0.05～P<0.005),而与患者的年龄、性别和肿瘤大小均无明显关系(P>0.05).结论:食管癌的MMP-2表达与肿瘤细胞的增殖以及肿瘤侵袭、转移相关,在食管癌的发展过程中起重要作用.MMP-2可作为评价食管癌恶性潜能的生物学标志物.
Objective：To investigate the expression of matrix metalloproteinase 2（MMP-2） and its oorrelation with expression of Ki67 and proliferative, invasiveness and metastasis in human esophageal carcinoma（EC）. Methods.The expressions of MMP-2 and Ki67 were detected in 75 cases of EC and 30 cases of oontrols by immunohistochemical stain（S-P method） and their relationship with the dinloopathologic factors was analyzed. Results：The positive rates of MMP-2 and Ki67 were 82.7% and 78.7% respectively in EC group.The positive rates of MMP-2 and Ki67 in EC group were significantly higher than those in oontrol group（P 〈 0.05）. The expressions of MMP-2 and Ki67 were detected in 51 cases, and the accord rate of was 74.7% （P 〉0.05）. The expression of MMP- 2 in EC group was oorrelated with vessel invasion, depth of invasion, and metastasis to the paraesophageal lymph nodes except age, sex and tumor size（ P 〈 0.05 - P 〈 0. 005 ）. Conclusions-The expression of MMP-2 in EC is closely related with proliferative, invasiveness and metastasis of toumor cell. Expression of MMP-2 might play an important role in the development of EC,and MMP- 2 become a biological marker for evaluating the malignant potential of EC.
出处
《蚌埠医学院学报》
CAS
2005年第5期383-385,共3页
Journal of Bengbu Medical College
基金
安徽省卫生厅自然科学研究资助项目(No.2002B075)
