摘要
活化T细胞核因子（NFAT）是一类具有多向调节功能的转录因子，在活化T细胞中，NFAT能与许多其它信号转导系统的转录因子在核内相互作用，完成不同信号间整合，激活特异性的基因表达。NFAT可能在Th0细胞的分化中起重要作用，并能调节Th2细胞因子的产生，在变态反应性疾病中具有重要意义。NFAT与哮喘也有很密切的关系。
The nuclear factor of activated T cells （NFAT） is a family of transcription factors having diverse function of the regulation. Not only NFAT proteins can interact with different transcription-factor partners in the nucleus, and also they are important integrators of calcium signaling with many other signaling pathways in T cells and activate specific gene expression. NFAT proteins may play an important role in Th0-cell development and allergy diseases, and also regulate production of Th2 cytokines. Thus, NFAT proteins can take part in the development of asthma.
出处
《国际呼吸杂志》
2007年第1期33-36,共4页
International Journal of Respiration
