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钙调神经磷酸酶-活化T细胞核因子与系统性红斑狼疮 被引量：2

Calcineurin-nuclear factors of activated T cells and systemic lupus erythematosus
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摘要 系统性红斑狼疮是一种以多种自身抗体产生为特点的侵犯多系统多脏器的自身免疫性疾病，其发病机制尚未明确，目前认为T淋巴细胞异常是SLE的发病的关键。钙调神经磷酸酶-活化T细胞核因子信号通路作为T细胞内重要的生物信号转导通路，在T细胞活化中起到调节枢纽的作用，了解CaN／NFAT信号途径在SLE中的作用及目前相关主要治疗药物的研究现状可为SLE的基础研究及临床治疗提供依据。 Systemic lupus erythematosus （SLE） is a systemic autoimmune disease characterized by the presence of auto-antibodies and the involvement of muhiple organs. The pathogenic mechanisms of SLE remain unclear, but recent studies have discovered that T cell subgroup is a key step in the activation of SLE. CaN- NFAT is an important signal transduction pathway in T cell. It plays a vital role in the activation of SLE T cells.
作者 张群燕 蔡辉
机构地区 南京军区南京总医院
出处 《国际免疫学杂志》 CAS 2012年第2期141-145,共5页 International Journal of Immunology
关键词 钙调神经磷酸酶-活化T细胞核因子 系统性红斑狼疮 Can-NFAT Systemic lupus erythematosus
分类号 R593.241 [医药卫生—内科学]
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参考文献40

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二级参考文献27

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共引文献6

同被引文献40

  • 1陈利华,蒋捍东,林存智.γ干扰素、白细胞介素18、白细胞介素12及可溶性白细胞介素2受体在结核性和恶性胸腔积液中表达意义分析[J].中华临床医师杂志（电子版）,2011,5(12):3602-3604. 被引量：13
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引证文献2

二级引证文献9

国际免疫学杂志
2012年 第2期

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