摘要
目的观察通心络对不稳定型心绞痛患者血清可溶性细胞间黏附分子-1(sICAM-1)水平的影响,探讨其治疗动脉粥样硬化性疾病的可能机制。方法将60例不稳定型心绞痛患者随机分为常规治疗组(30例)和通心络组(30例),常规治疗组予常规治疗,通心络组在常规治疗的基础上加用通心络。监测治疗前后血清sICAM-1和血浆血脂水平的变化。结果2组治疗后血浆总胆固醇(TC)和低密度脂蛋白(LDL-C)水平均较治疗前明显下降(P<0.05),但2组间比较差异无显著意义;2组甘油三酯(TG)治疗后均下降,高密度脂蛋白胆固醇(HDL-C)治疗后均升高,但治疗前后比较差异均无显著意义(P>0.05)。通心络组血清sICAM-1水平由治疗前的(129.37±32.29)ng/ml下降到治疗后的(78.42±26.42)ng/ml,常规治疗组血清sICAM-1水平由治疗前的(122.32±36.12)ng/ml下降到治疗后的(89.24±21.25)ng/ml,治疗后均有明显降低,且治疗后通心络组sICAM-1水平明显低于同期常规治疗组(均P<0.05)。结论通心络能明显降低不稳定型心绞痛患者血清sICAM-1含量,具有抑制动脉血管壁炎症、保护血管内皮细胞的作用。
Objective To observe the effect of Tongxinluo on soluble intercellular adhesion molecule-1 （sI- CAM-1 ） in patients with unstable angina pectoris.Methods 60 eases with unstable angina pectofis were randomly di- vided into treatment group （ n = 30,routine treatment added Tongxinluo） and control group （ n = 30,routine treatment）. Before and after 1 month＇ s treatment i sICAM- 1 in serum and blood lipids were measured. Results After treat- ment, the cocentrations of serum TC and LDL-C were significantly decreased in both group （ P 〈 0.05）, but there was no difference between two groups. The levels of TG decreased and HDL-C increased in both group,but there were no significant difference in two groups （ P 〉 0.05）. The level of serum slCAM-1 was decreased from （ 129.37± 32.29） ng/ml to （78.42 ± 26.42） ng/ml in treatment group, and decreased from （ 122.32±36.12）ng/ml to （89.24 ±21.25） ng/ml in coutrol group,and it was lower in Tongxinluo group than that in control group （ P 〈 0.05）. Conclusions Tongxinluo can decrease the level of serum sICAM- 1 in patients with unstable angina pectofis, it suggests that Tongxinluo maybe depress vascular imflammatian and protect endothelial cells.
出处
《疑难病杂志》
CAS
2007年第1期4-6,共3页
Chinese Journal of Difficult and Complicated Cases
关键词
通心络
不稳定型心绞痛
细胞间黏附分子-1
Tongxinluo
Angina pectoris, unstable
Intercellular adhesion molecule- 1
