摘要
目的:观察静脉溶栓治疗对急性心肌梗死(AMI)患者血清可溶性细胞间黏附分子-1(sICAM-1)和高敏C反应蛋白(hs-CRP)的影响。方法:采用ELISA法测定30例接受静脉溶栓治疗的AMI患者(溶栓组)和35例未接受静脉溶栓治疗的AMI患者(对照组)入院治疗前、治疗后48、72、96、120、144小时血清sICAM-1和hs-CRP水平。结果:(1)溶栓组在治疗后48、72、96、120、144小时血清sICAM-1和hs-CRP水平较对照组明显降低(P<0.05),治疗前两组差异无显著性(P>0.05);(2)溶栓组在治疗后120、144小时血清sICAM-1和hs-CRP水平差异有非常显著性(P<0.01)。结论:静脉溶栓治疗可显著降低AMI患者血清sICAM-1和hsCRP的水平,其测定可作为病情预后观察的一个指标。
Objective ：To observe the effect of intravenous thrombolysis on serum soluble intercellular adhesion molecule-l（sICAM- 1） and hs-C-reactive protein （hs-CRP） in the patients with acute myocardial infarction（AMI）.Methods：The level of serum sICAM-1 and hs-C-reactive protein （hs-CRP）between intravenous thrombolysis group（n=30） and control group（n=35） were measured using ELISA be-fore and at 48,72,96,120,144 h after treatment.Results：The levels of serum sICAM-1 and hs-CRP in intravenous thrombolysis group were significantly lower than those in control group after treatment（P〈0.05）,especially at 120 h and 144 h（P〈0.01 ）.Conclusion：Intra- venous thrombolysis can significantly reduce the level of serum sICAM-1 and hs-CRP in the patients with AMI.Semm sICAM-1 and hs- CRP can be served as a clinical index of prognosis of AMI.
出处
《现代医药卫生》
2009年第18期2765-2766,共2页
Journal of Modern Medicine & Health
