摘要
目的:探讨叶酸干预治疗对高血压患者血管内皮功能及血浆同型半胱氨酸水平的影响。方法:将60例轻、中度原发高血压患者随机分为叶酸干预组(30例)和对照组(30例),采用酶标免疫吸附法测定治疗前及治疗12周后血浆同型半胱氨酸水平及内皮素、一氧化氮水平。结果:叶酸治疗12周后血浆同型半胱氨酸、内皮素水平有明显降低(P<0.01),一氧化氮水平明显升高(P<0.01)。结论:叶酸干预治疗能降低血浆同型半胱氨酸水平,对高血压患者血管内皮功能损害有一定的改善作用。
Objective To evaluate the effect of oral folie acid on endothelial function as well as plasma homoeysteine in hypertensive patients. Methods Sixty patients with mild to moderate essential hypertension were divided randomly into two groups, folie acid administration group （30 cases） and control group （30 cases）. The level of plasma homoeysteine, endothelin and nitric oxide were measured before and 12 weeks after treatment. Results Plasma homoeysteine and endothelin were reduced significantly compared with those of pretreatment （P〈0. 01）, but the nitric oxide was increased significantly compared with that of pretreatment （P 〈0. 01 ）. Conclusion Folie acid administration reduces plasma homoeysteine and improves arterial endothelial function in hypertensive patients.
出处
《实用诊断与治疗杂志》
2007年第1期5-7,共3页
Journal of Practical Diagnosis and Therapy
