摘要
炎症对几乎所有的心血管相关疾病的发生和发展都起着重要的作用,炎症在动脉粥样硬化中的关键性作用已确定,而高血压作为动脉粥样硬化重要危险因素,亦可能是一种慢性低级别炎症反应。近来的研究发现血压的升高与C-反应蛋白(CRP)等炎症因子呈高度正相关,炎症可促进高血压的发生与发展,同时炎症与高血压心肌纤维化及高血压血管重构有密切相关。近来的临床实验如ASCOT-LLA结果表明抑制高血压患者的炎症可使胆固醇正常的高血压患者主要心血管事件相对危险度下降36%。本文就炎症与高血压及其心肌纤维化和血管重构等进行综述,并对其临床意义进行探讨。
Inflammatory processes appear to play an important role in the pathogenesis of cardiovascular diseases. It has been established that inflammation has a pivotal role in the atherosclerosis. As a major risk factor contributed to atherosclerosis, hypertension seems to be a chronically low-grade inflammation process, lots of studies suggested that blood pressure elevation is significantly positive correlation with the levels of inflammatory mediators, such as C-reactive protein. Inflammation may promote the process of hypertension. Furthermore, inflammation is highly associated with cardiac fibrosis and vascularremodeling in hypertension. Current clinical trials, for example, ASCOT-LLA suggested that use atorvastatin to reduce the inflammatory reaction in hypertensive patients with normal concentration of cholesterol would decrease the major cardiovascular events （relative risk reduction 36% ）. This paper summarizes the association inflammation with hypertension as well as cardiac fibrosis and vascular remodeling, and tries to explore the clinical significance of the association.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2006年第2期136-140,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
人事部回国人员2004年资助项目
关键词
高血压
炎症
心肌纤维化
血管重构
hypertension
inflammation
cardiac fibrosis
vascular remodeling
