摘要
背景与目的血管内皮生长因子C(VEGF-C)可以诱导淋巴管上皮细胞增殖和淋巴窦的新生。本研究的目的是探讨VEGF-C的表达与非小细胞肺癌淋巴结转移的关系。方法应用免疫组织化学S-P法对60例非小细胞肺癌组织中VEGF-C蛋白的表达进行测定,并结合肺癌的淋巴结转移特征进行分析。结果肺癌组织中VEGF-C蛋白阳性表达率为65.00%(39/60)。有淋巴结转移组VEGF-C蛋白阳性表达率83.33%(20/24)明显高于无淋巴结转移组52.78%(19/36)(P<0.05)。结论肺癌组织中存在VEGF-C的高表达,可能与肺癌的淋巴结转移有关。VEGF-C蛋白表达可能作为推断肺癌淋巴结转移的参考指标。
Background and objective It has been showed that VEGF-C can induce the proliferation of lymphocytes. The aim of this study is to explore the expression of VEGF-C in human non-small cell lung cancer （NSCLC） and its relationship with lymph node metastasis. Methods The expression of VEGF-C was examined in 60 human NSCLC tissues by immunohistochemical technique. Results The positive rate of VEGF-C expression was 65.00% （39/60） in NSCLC tissues. The expression of VEGF-C was significantly higher in cases with lymph node metastasis （83. 33%, 20/24） than in those without lymph node metastasis （52.78%, 19/ 36） （P〈0.05）. Conclusion There is an overexpression of VEGF-C protein in human NSCLC tissues, which may correlate with lymph node metastasis. The expression of VEGF-C protein might be used as a useful marker of lymph node metastasis in NSCLC.
出处
《中国肺癌杂志》
CAS
2006年第6期516-518,共3页
Chinese Journal of Lung Cancer
