摘要
合成了大分子引发剂壳聚糖（CS）接枝α-溴代异丁酰溴（CS-Br）,然后利用原子转移自由基聚合（ATRP）合成了一种新型pH敏感性的壳聚糖材料——壳聚糖接枝α-溴代异丁酰溴共聚甲基丙烯酸聚乙二醇酯P（CS-Br-PEGMA）,并对其结构进行了表征,研究了其对辅酶A（CoA）的控制释放,结果发现在24℃、P（CS-Br-PEGMA）在不同浓度或pH在3.7～9之间变化时,聚合物都能对辅酶A进行控制释放,同时对其控制释放机理进行初步探讨.
A pH-sensitive chitosan material was prepared via atom transfer radical polymerization （ATRP） of chitosan with poly （ethylene glycol） methacrylate （PEGMA）,which was successfully conducted in water and methanol system with CS-Br as macroinitiator and CuBr/bpy as a catalyst. The copolymer obtained was analyzed, The results of UV analysis showed that at 24℃ and under different concertration or at 24℃ and with pH value between 3.7 - 9, P（CS-Br-PEGMA） can well control delivery on coenzyme A, and the release mechanism of coenzyme A was also discussed.
出处
《现代化工》
EI
CAS
CSCD
北大核心
2006年第10期49-51,53,共4页
Modern Chemical Industry
基金
国家自然科学基金资助项目(50273010)
