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肿瘤坏死因子基因多态性与动脉血栓性疾病关系的研究进展 被引量：2

Progress in Study for Gene Polymorphism of Tumor Necrosis Factor and artery Thrombotic Disease
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摘要 肿瘤坏死因子（tumor necrosis factor，TNF）是一类具有多种生物学活性的前炎性细胞因子。它不仅有抗肿瘤、抗病毒与免疫调节的作用，而且可以直接或间接损伤血管内皮细胞，产生促炎症、促凝血、抗纤溶反应，从而在血栓形成、动脉粥样硬化、DIC等许多疾病发病机制中起重要作用。近年来，通过对血栓患者重要炎性介质进行基因型分析，发现TNF基因多态性可能与血栓性疾病的的易感性有关。
作者 余卓丽 涂传清
机构地区 深圳市宝安区人民医院血液科
出处 《血栓与止血学》 2006年第5期225-227,共3页 Chinese Journal of Thrombosis and Hemostasis
关键词 肿瘤坏死因子 基因多态性 冠心病 脑梗死
分类号 Q754 [生物学—分子生物学]
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参考文献24

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二级参考文献32

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共引文献106

同被引文献17

  • 1李艳,汪明,张平安,陈会,蒋学俊,黄从新.肿瘤坏死因子-β基因G252A、C804A多态性与冠状动脉粥样硬化性心脏病的相关性[J].中华医学遗传学杂志,2004,21(6):583-586. 被引量：7
  • 2张宏卫,刘丽华.脑梗死与基因多态性[J].中国临床康复,2005,9(29):149-151. 被引量：2
  • 3张国忠,潘速跃,陆兵勋,李伟.肿瘤坏死因子α及β基因多态性与脑梗死关系的研究[J].中国现代医学杂志,2007,17(7):813-816. 被引量：10
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二级引证文献4

血栓与止血学
2006年 第5期

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