摘要
目的:探讨肿瘤坏死因子(TNF)基因多态性与Graves病(GD)的关系。方法:用序列特异性引物聚合酶链反应技术(PCR-SSP)检测TNF等位基因及基因型。结果:TNF+488、-308等位基因及基因型分布在GD组与健康对照组之间、在不同性别、有无GD家族史、有无甲状腺相关眼病(TAO)GD亚组之间差异无统计学意义。结论:TNF+488、-308基因多态性与山东汉族GD患者发病无关联。
Objcetive: To investigate the association of the polymorphisms of tumour necrosis factor (TNF)-ɑ gene with Graves disease (GD). Method: Allele and genotype frequencies were determined by polymerase chain reaction and sequence specific primers (PCR-SSP). Result: Allele and genotype frequencies of TNFɑ +488, -308 were not significantly different between GD and control groups. There were also no significant difference between male and female GD, GD with and without GD familial history, GD with and without thyroid-related ophthalmopath (TAO) groups. Conclusion: There are no association between polymorphisms of TNFɑ +488, -308 genes and GD susceptibility in Hans nationals in Shandong Chinese.
出处
《山东大学学报（医学版）》
CAS
北大核心
2005年第6期500-503,共4页
Journal of Shandong University:Health Sciences
基金
山东省卫生厅基金资助项目(2001CA1CJB10)
