摘要
目的检测人型支原体(Mh)对14环(红霉素、罗红霉素和克拉霉素)、15环(阿奇霉素)和16环(交沙霉素)大环内酯类药物的敏感性,为临床合理用药提供参考依据。方法采用微量肉汤稀释法检测了5种大环内酯类药物对106株Mh的最低抑菌浓度(MIC)。结果在5种药物中,交沙霉素抗Mh活性最强,MIC50为0.125 mg/L,MIC90为0.5 mg/L,较弱的为罗红霉素、克拉霉素和阿奇霉素,其MIC50分别为4 mg/L3、2 mg/L和64 mg/L,MIC90分别为32 mg/L1、28 mg/L和512 mg/L,最弱的为红霉素,MIC50为64 mg/L,MIC90为512 mg/L,结论Mh对大环内酯类药物存在不同程度的耐药,16环大环内酯类药物交沙霉素,抗Mh活性强于14环和15环大环内酯类药物。
Objective To determine the susceptibility of Mycoplasma hominis（Mh） to 14 - membered（erythromycin, roxithromycin and clarithromycin ）, 15 - melnbered （ azithromycin ） and 16 - membered （josamycin） macrolides, and to provide the basis for the rational use of antibiotics. Methods The MIC of five macrolides against 106 strains of Mh were determined using broth microdilution method. Results Among the five macrolides, josamycin were the most active agents against Mh with the MIC50 being 0. 125 rag/L, MIC50 being 0. 5 mg/L; roxithromycin, clarithmmycin and azithromycin were less active against Mh with the MIC50 being 4 rag/L,32 mg/L and 64 mg/L, respectively and MIC50 being 32 rag/L, 128 mg/L and 512 mg/L, respectively; Eryhthromycin had the least activity against Mh,with MIC50 and MIC50 being 64 mg/L and 512 mg/L. Conclusion The degree of resistance of Mh to different macrolides varied 16 - membered maerolides such as josamycin is more active against Mh than 14 - membered and 15 - membered macrolides.
出处
《南华大学学报（医学版）》
2006年第3期340-342,353,共4页
Journal of Nanhua University(Medical Edition)
关键词
人型支原体
大环内酯类药物
敏感性
最低抑菌浓度
mycoplasma holninis
macrolides
susceptibility
minimum inhibitory concentration（MIC）
