摘要
目的 了解广东省湛江地区淋病流行菌株对抗生素的敏感性。方法 采用纸片扩散法对 1998年～ 1999年间广东省湛江地区分离出的 98株淋球菌临床分离株进行了药物敏感性测定。根据淋球菌对 2 1种抗生素的抑菌圈直径(mm)与“抗菌药物药敏试验判断标准”来确定药物敏感性。结果 在测定的 2 1种抗生素中 ,对淋球菌敏感性较高的 5种抗生素依次为壮观霉素、头孢三嗪、哌啦西林、优立新、阿齐霉素 ,其敏感率分别为 87.76 %、86 .73 %、86 .73 %、82 .6 5 %、79.5 9%。而淋球菌耐药性较高的 5种抗生素依次为依诺沙星、洛美沙星、环丙沙星、诺氟沙星和氧氟沙星 ,耐药率分别为92 .86 %、89.90 %、82 .6 5 %、82 .6 5 %和 81.6 3 %。结论 湛江地区目前流行的淋球菌菌株耐药形势严峻 ,尤以氟喹诺酮类药物为甚 ,临床常用的头孢三嗪。
Objective To evaluate the antibiotic susceptibility on Neisseria gonorrhoeae strains in Zhan jiang(Guang dong). Method 98 gonococcal isolates obtained from 1998 through 1999 in Zhan jiang were tested for their susceptibilities to 21 antibiotic agents using disk diffusion method in vitro. The inhibition zone diameters(mm) were then identified based on “The interpretive criteria for susceptibility test to gonococci” and the susceptibility of the antibotics was thus be determined. Result Of all these 21 antibiotic agents, the higher susceptibilities to gonococci were spectinomycin, ceftriaxone, piperacillin, ampicillin/sulbactam and azithromycin in turn, the percentage of susceptibilities were 87.76%, 86.73%, 86.73%, 82.65% and 79.59%, respectively. On the other hand, the higher resistances to gonococci were enoxacin, lomefloxacin, ciprofloxacin, norfloxacin and ofloxacin. The percentages of resistance were 92.86%, 89.90%, 82.65%, 82.65% and 81.63%, respectively. Conclusion The study indicated that the resistant gonococci isolates in Zhan jiang were serious, especially the fluoroquinolone resistance. We should also pay more attention to the ceftriaxone and spectinomycin resistance.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2000年第3期176-177,共2页
The Chinese Journal of Dermatovenereology
基金
广东省卫生厅"五个一工程"基金资助!(编号9601)
关键词
淋病奈瑟菌
纸片扩散法
药物敏感性
Neisseria gonorrhoeae Disk diffusion Antibiotic susceptibility
