摘要
本实验通过观察摄入ＡＦＢ１及Ｇｅ－１３２后Ｗｉｓｔａｒ大鼠和昆明小鼠体内ＳＯＤ活力的变化，进一步了解ＡＦＢ１代谢途径和Ｇｅ－１３２与自由基的关系。实验表明，摄入ＡＦＢ１的ＳＯＤ活力受到抑制，而摄入Ｇｅ－１３２后ＳＯＤ活力得到提高，且一次性摄入ＡＦＢ１后ＳＯＤ活力最终得到恢复，其中大鼠对ＡＦＢ１敏感性相对较大。
In order to investigate AFB1metabolic pathway in vivo and relationship between Ge-132 and the free radical, the SOD activity in Wistar rats and Kunming mices. which had been intaken AFB, and Ge-132 before and after were determined.The results showed that the changing tendency of SOD in rats and mices was lar. AFB, could signficantly reduce the SOD activity in red blood cell, serum and liver tissue. The SOD activity both in rats and mices was stimulated after intaken Ge-132. Inhibitory of the SOD activity by single injection AFB, graduated away at last. Wistar rats were more sensitive to AFB, than Kunming mices.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1996年第6期344-346,共3页
Cancer Research on Prevention and Treatment
基金
广西卫生厅青年基金
关键词
黄曲霉毒素B1
超氧化物歧化酶
锗132
Aflatoxin B_1 (AFB_1 )
Carboxyethylgermanium (Ge-132)
Superoxide Dismutase(SOD)
