摘要
Ge-132体内外给药的剂量分别是5mg/kg和3.3—2062.5μg/ml时,均显著地抑制花生四烯酸和Ca^(2+)诱导的血小板聚集作用。体外实验证明对凝血酶诱导的聚集无效,但能显著地抑制可乐定诱导的聚集作用。
Carboxyethylgermanium sesquioxide ( Ge-132 ) was given in the dosage of 3.3 - 2062.5μg/ml in vitro or 5mg/kg iv in rabbits. The results suggested that Ge-132 inhibited arachidonic acid and Ca2+-induced platelet aggregation. In the former cases, the inhibition rates were of 15-100% in vitro and 27-38% in vivo, and in the latter cases, of 4-34% in vitro and 26-35% in vivo. In vitro, it was shown that Ge-132 did not inhibit thrombin-induced platelet aggregation, but inhibit cloni dine - induced aggregaton significantly.
出处
《第一军医大学学报》
CSCD
1989年第3期214-216,共3页
Journal of First Military Medical University
关键词
有机锗
血小板聚集
花生四烯酸
carboxyethylgermanium sesquioxide
platelet aggregation
arachidonic acid
thrombin
calcium chloride
clonidine
