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糖尿病患者血清超敏C反应蛋白、白细胞介素-6及白细胞介素-10的变化 被引量:4

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摘要 目的:研究血清超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)和白细胞介素-10(IL-10)在糖尿病患者中的变化,及其对心血管并发症的预示作用。方法:收集99例糖尿病患者血清,其中胆固醇正常者68例,胆固醇升高者31例,及50例正常体检人员的血清。使用乳胶增强免疫透射比浊法检测hs-CRP,一步酶法检测胆固醇,同时采用ELISA双抗体夹心法测定血清IL-6、IL-10。结果:正常对照组血清hs-CRP、IL-6和IL-10浓度分别为(1.66±0.95)mg/L、(24±8)ng/L和(27±7)ng/L,胆固醇正常糖尿病组血清hs-CRP、IL-6和IL-10浓度分别为(2.77±1.19)mg/L、(25±10)ng/L和(28±8)ng/L,胆固醇升高糖尿病组血清hs-CRP、IL-6和IL-10浓度分别为(5.70±1.81)mg/L、(34±10)ng/L和(21±5)ng/L。与正常对照组、胆固醇正常糖尿病组相比,胆固醇升高糖尿病组hs-CRP、IL-6和IL-10表达水平差异均有统计学意义(分别为P<0.01、P<0.05、P<0.05)。与正常对照组比较,胆固醇正常糖尿病组hs-CRP高表达(P<0.05),而这两组间IL-6和IL-10表达水平差异无统计学意义(P>0.05)。结论:炎症因子hs-CRP在预测糖尿病患者并发冠心病中具有重要的临床意义。
出处 《实用医学杂志》 CAS 2006年第17期1995-1997,共3页 The Journal of Practical Medicine
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参考文献9

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二级参考文献12

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