摘要
目的 探讨血清超敏C反应蛋白(hs-CRP)和血清白细胞介素6(IL-6)在糖尿病并发动脉粥样硬化的临床价值。方法 用岛津7200生化分析仪胶乳增强免疫比浊法检测血清hs-CRP,一步法检测低密度脂蛋白胆固醇(LDL-C);采用ELISA双抗体夹心法测定血清IL-6。结果 糖尿病患者LDL-C升高组,血清hs-CRP浓度为(6.81±3.32)mg/L,IL-6为(17.2±5.6)ng/L,两者呈显著正相关,r=0.61;P<0.01。糖尿病患者LDL-C正常组hs-CRP为(3.81±1.86)mg/L,IL-6为(9.2±3.9)ng/L,呈明显正相关,r=0.46,P<0.01。健康组血清hs-CRP为(0.76±0.65)mg/L,血清IL-6为(5.8±2.1)ng/L,r=0.136,两者无明显相关性(P>0.05)。结论 糖尿病患者血清IL-6参与诱导肝急性时相蛋白(CRP)的合成,并共同参与糖尿病动脉粥样硬化的病理过程。
Objective To discuss the clinical value of high-sensitivity C-Reactive protein ( hs-CRP) and Interlukin-6 (IL-6) on patients with diabetes mellitus and athero sclerosis. Methods Serum hs-CRP is measured through particle enhanced immuoturbidimetric method by using analysis instrument 7200 . LDL-C is examined by one-step method. IL-6 is measured by double antibody assay. Results (1) Diabetic with higer LDL-C: the density of serum hs-CRP is (6. 81 ±3. 32) mg/L. IL-6 is (17. 2 ±5. 6) mg/L . Both are remarkably positive related. related coefficient r = 0. 61 ;P <0. 01. (2) Diabetic with normal LDL-C: hs-CRP is (3. 81 ± 1. 86) mg/L. IL-6 is (9. 2±3. 9) mg/L. Both are remarkably positive related . (3) For healthy sample. hs-CRP is ( 0. 76 ± 0. 65 ) mg/L . IL-6 is ( 5. 8 ±2.1) mg/L related coefficient r = 0. 136. Both are not obviously related (P >0. 05). Conclusion For diabetic serum IL-6 plays roles in inducing the synthetic of CRP when there is an acute liver and also plays roles in the pathologic process of diabetes athero sclerosis.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2004年第5期315-317,共3页
Chinese Journal of Laboratory Medicine
