摘要
目的探讨不同性别的2型糖尿病(T2DM)患者血清谷氨酰转移酶(γ-GGT)水平与多种心血管危险因素之间的相关性。方法286例T2DM患者先按性别分组,再按γ-GGT四分位数分组。比较各组间体质指数(BMI)、腰围、血压、肝功能全项、血脂、血糖等生化指标。结果不同性别的T2DM患者BMI、腰围、舒张压(DBP)、三酰甘油(TG)、尿酸(UA)、γ-GGT、年龄、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1c)、高敏C反应蛋白(hsCRP)以及血浆纤维蛋白原(FIB)水平差异有统计学意义。γ-GGT水平不同时,男性的年龄、病程、BMI、腰围、收缩压(SBP)、DBP、TG、总胆固醇(TC)、丙氨酸转氨酶(ALT)以及天冬氨酸转氨酶(AST)水平差异有统计学意义,女性的腰围、TC、LDL-C、hsCRP、ALT、AST以及碱性磷酸酶(ALP)水平差异有统计学意义;男性γ-GGT与年龄和病程呈负相关,与BMI、腰围、DBP、TG、TC、hsCRP及UA呈正相关,女性γ-GGT与腰围、TC、低密度脂蛋白胆固醇(LDL-C)、HbA1c、hsCRP及UA呈正相关;BMI和TC升高是男性γ-GGT的独立危险因素,腰围大和hsCRP高是女性γ-GGT的独立危险因素。结论T2DM患者血清γ-GGT与多种心血管危险因素相关,其对糖尿病患者心血管并发症的预示作用值得重视和研究。
Objective To explore the correlation between serum gamma glutamyhransferase （γ-GGT） and cardio- vascular risk factors in different genders with type 2 diabetes mellitus. Methods A total of 286 patients with type 2 diabe- tes were divided into male group and female group, and then each group was sub-divided into four groups according to the quartile of serum γ-GGT level. The values of body mass index （BMI）, waist, systolic pressure （SBP）, diastolic pressure （DBP）, triglyceride （TG）, cholesterol （TC）, high-density lipoprotein cholesterol （HDL）, low-density lipoprotein cholesterol （LDL）, fast- ing plasma glucose （FPG）, glyeated hemoglobin （HbAlc）, high sensitive c-reactive protein （hsCRP） and uric acid （UA） were compared between groups. Results There were significant differences in BMI, waist, DBP, TG, TC, UA, γ-GGT, age, HDL-C, HbAlc, hsCRP and plasma fibrinogen （FIB） between different genders with type 2 diabetes mellitus. There were sig- nificant differences in age, duration of disease, BMI, waist, SBP, DBP, TG, TC, alanine aminotransferase （ALT） and aspartate aminotransferase （AST） in male subjects with different γ-GGT levels. There were significant differences in waist, TC, LDL-C, hsCRP, ALT,AST and alkaline phosphatase （ALP） in female. The level of γ-GGT was negatively correlated with age and dura- tion of disease in male patients. But it was positively correlated with BMI, waist, DBP, TG, TC, hsCRP and UA in male pa- tients. In female patients, the level of γ-GGT was positively correlated with waist, TC, LDL-C, HbAle, hsCRP and UA. Val- ues of BMI and TC were the independent risk factors of γ-GGT in male patients. Values of waist and hsCRP were the indepen- dent risk factors of γ-GGT in female patients. Conclusion The serum γ-GGT is closely related with several cardiovascular risk factors in patients with type 2 diabetes mellitus, which deserves attention and research in predicting the cardiovascular complication of diabetes.
出处
《天津医药》
CAS
北大核心
2013年第2期114-118,共5页
Tianjin Medical Journal
关键词
糖尿病
2型
心血管疾病
危险因素
血脂异常
C反应蛋白质
Γ-谷氨酰转移酶
diabetes mellitus, type 2
cardiovascular diseases
risk factor
dyslipidemias
C-reactive protein
gam-ma-glutamyltransferase [Key words] diabetes mellitus, type 2
cardiovascular diseases
risk factor
dyslipidemias
C-reactive protein
gam-ma-glutamyltransferase
