摘要
目的:观察银杏叶提取物金纳多对内毒素(LPS)所致急性肺损伤是否具有保护作用。方法:腹腔注射内毒素制备小鼠急性肺损伤模型,分别于内毒素损伤前12 h和2 h给予银杏黄酮配糖体金纳多注射液预处理,观察金纳多内毒素所致小鼠的肺组织湿/干重比和支气管肺泡灌洗液蛋白浓度、肺组织脂质过氧化产物丙二醛(MDA)及一氧化氮(NO)变化和肺组织病理改变的影响。结果:金纳多注射液预处理可有效降低LPS所致肺组织湿/干重比和肺泡灌洗液蛋白浓度的增高(P(0.05和P(0.01),降低LPS所致肺组织MDA和NO含量的增高,减轻LPS所致的肺组织病理改变。结论:金纳多预处理对内毒素所致急性肺损伤具有保护作用。
Objective： To observe if the extract of gingko leaves, ginaton, has a protection on the acute lung injury caused by lipopolysaecharide（LPS）. Method： the mice models of acute lung injury were created by injecting LPS into abdominal cavity, the pretreatment was done with the ginkgetin glycoeonjugate ginaton injection respectively at 12 and 2 hours prior to LPS damage, some targets, such as the ratio between wet and dry weight in lung tissue, the concentration of albumen in bronchoalveolar lavage fluid, the change of lipid peroxidation product MDA and NO in lung tissue, the effects on pathological changes in lung tissue, were observed. Result： The pretreatment of Ginaton injection could effectively decrease the ratio between wet and dry weight in lung tissue, the concentration of albumen in bronchoalveolar lavage fluid to raise up, which was caused by LPS （ P 〈 0.05, P 〈 0.01 ） ; and lower the content of MDA and NO, lighten the pathological change of lung. Conclusion： The pretreatment of Ginaton has an obvious protection on the acute lung injury caused by LPS.
出处
《中医药导报》
2006年第8期13-15,19,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
湖南省财政厅
教育厅高校科研基金(05C016)
