摘要
目的:探讨丁香酚抑制脂多糖所致发热的机制。方法:建立大鼠脂多糖性发热模型,观察丁香酚对大鼠直肠温度的影响,放免法测定大鼠血浆及脑脊液中精氨酸加压素(AVP)含量的变化。结果:腹腔注射脂多糖溶液后大鼠直肠温度明显升高(P<0．01),血浆及脑脊液中AVP的含量也明显升高(P< 0．05);丁香酚能明显抑制脂多糖所致大鼠发热反应(P<0．01),同时血浆及脑脊液中AVP含量也进一步增加(P<0．05)。结论:丁香酚通过增加体内AVP的含量而发挥解热作用。
Objective：To study the mechanisms of eugenol suppressing LPS-induced fever in rats. Methods： Feverish rat model was established by intraperitoneal injection （i. p. ） of LPS. The effects of eugenol on rectal temperature of the rats were observed, and the changes of arginine vasopressin （AVP） content in plasma and CSF were determined with radioimmunoassay. Results： Intraperitoneal injection of LPS significantly increased rectal temperature （P〈0.01）, AVP content in both plasma and CSF （ P 〈 0.05）. Eugenol had markedly inhibitory effects on the LPS-induced fever in rats （P〈0.01）, and AVP content in both plasma and CSF increased significantly （P〈0.05） after eugenol administration. Conclusions： Eugenol may have antipyretic effects by decreasing AVP content.
出处
《承德医学院学报》
2006年第3期227-229,共3页
Journal of Chengde Medical University
