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由不同接头分子介导的Toll样受体信号通路 被引量:5

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摘要 Toll样受体(Toll-likereceptors,TLRs)是一类重要的模式识别受体(patternrecognitionreceptors,PRR)。Toll样受体信号通路既激活先天性免疫又对获得性免疫应答的启动发挥重要作用。一类包含TIR结构域的接头分子如MyD88、TIRAP、TRIF、TRAM可募集到不同Toll样受体的TLR胞质区,转导特异的信号通路。依据信号通路中接头分子的不同,Toll样受体信号通路一般分为MyD88依赖型信号通路和MyD88非依赖型/TRIF依赖型信号通路。
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2006年第4期544-546,共3页 Chinese Journal of Cellular and Molecular Immunology
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