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Toll样受体信号通路与缺血性中风炎症反应机制的研究进展 被引量：9

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摘要 Toll样受体既是机体天然免疫信号受体,同时也是炎症信号受体,在脑缺血发生后通过MyD88依赖性途径和TRIF依赖性途径参与炎症级联反应。阻断或者激活相应的Toll样受体信号传导通路,可有效抑制脑缺血急性期炎症级联反应的发生、发展,减轻炎性损伤。干预Toll样受体信号传导通路是脑缺血后抗炎治疗的途径之一。
作者 尤晓欣 裴建
机构地区 上海中医药大学附属龙华医院针灸科
出处 《国际神经病学神经外科学杂志》 2014年第2期138-141,共4页 Journal of International Neurology and Neurosurgery
基金 上海市卫生局科研重点项目(2010003) 上海市卫生局海派中医流派传承研究基地项目(ZYSNXD-CC-HPGC-JD-004) 国家中医药管理局重点学科建设项目资助
关键词 卒中 缺血 炎症 TOLL样受体
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献28

  • 1Lloyd-Jones D, Adams RJ, Brown TM, et al. Heart disease and stroke statistics-2010 update: a report from the Ameri- can Heart Association. Circulation, 20 1 0, 121 ( 7 ) : e46- e215.
  • 2Meisel C, Meisel A. Suppressing immunosuppression afterstroke. N Engl J Med, 2011, 365(22) : 2134-3136.
  • 3Koenneeke HC, Balz W, Berfelde D, et al. Factors influen- cing in-hospital mortality and morbidity in patients treated on a stroke unit. Neurology, 2011 , 77 ( 10 ) : 965-972.
  • 4Eltzsehig HK, Eekle T. lsehemia and repeffusion-from mech- anism to translation. Nat Med, 2011 , 7 ( 11 ) : 1391- 1401.
  • 5顾悦华,尤晓欣,裴建.基质金属蛋白酶:一个缺血性脑卒中急性期的治疗靶点[J].国际神经病学神经外科学杂志,2013,40(3):266-270. 被引量：6
  • 6Leung PY, Stevens SL, Packard AE, et al. Toll-like recep- tor 7 preconditioning induces robust neuropmtection against stroke by a novel type I interferon-mediated mechanism. Stroke, 2012, 43(5) : 1383-1389.
  • 7Stevens SL, Ciesielski TM, Marsh B J, et al. Toll-like re- ceptor 9: A new target of ischemic preconditioning in the brain. J Cereb Blood Flow Metab, 2008, 28 (5) : 1040- 1047.
  • 8Downes CE, Crack PJ. Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS? Br J Pharmacol, 2010, 160(8) : 1872-1888.
  • 9Khandoga AG, Khandoga A, Anders ILl, et al. Postischemic vascular permeability requires both TRL-2 and TRL-4, but only TRL-2mediates the transendothelial migration of leuko- cytes. Shock, 2009, 31(6): 592-598.
  • 10Wang YC, Lin S, Yang QW. Toll-hke receptors in cerebral ischemic inflammatory injury. J Neuroinflamm, 2011, 8: 134-144.

二级参考文献36

  • 1Ramos-Fernandez M, Bellolio MF, Stead LG. Matrix metallo- proteinase-9 as a marker for acute ischemic stroke : a systematic review. J Stroke Cerebrovasc Dis, 2011, 20( 1 ): 47-54.
  • 2del Zoppo GJ. The neurovascular unit, matrix proteases, and in- nate inflammation. Ann N Y Acad Sci, 2010, 1207: 46-49.
  • 3Sumii T, Lo EH. Involvement of matrix metalloproteinase in thrombolysis- associated hemorrhagic transformation after embolie focal isehemia in rats. Stroke, 2002, 33 ( 3 ) : 831-836.
  • 4Yang Y, Estrada EY, Thompson JF, et al. Matrix metallo- proteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloprotein- ase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab. 2007, 27 (4) : 697 -709.
  • 5Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron, 2008, 57 : 178-201.
  • 6Tsuji K, Aoki T, Tejima E, et al. Tissue plasminogen activa- tor promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke, 2005 , 36 ( 9 ) : 1954-1959.
  • 7Wahlgren N, Ahmed N, Davalos A, et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Imple- mentation of Thrombolysis in Stroke-Monitoring Study (SITS- MOST ) : an observational study. Lancet, 2007, 369 (9558) : 275-282.
  • 8Bluhmki E, Chamorro A, Da valos A, et al. Stroke treatment with alteplase given 3.0 - 4.5 h after onset of acute ischae- mic stroke ( ECASS Ⅲ) .. additional outcomes and subgroup analysis of a randomised controlled trial. Lancet Neurol, 2009, 8(12) : 1095-1102.
  • 9Sumii T, Lo EH. Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats. Stroke, 2002, 33(3) : 831-836.
  • 10Suzuki Y, Nagai N, Umemura K, et al. Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice. J Thromb Haemost, 2007, 5 (8) : 1732-1739.

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国际神经病学神经外科学杂志
2014年 第2期

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