摘要
Toll样受体家族(Toll like receptors,TLRs)是先天性免疫系统进化过程中形成的非常保守的模式识别受体家族,Toll样受体2(Toll-like receptors 2,TLR2)是已经克隆的Toll样受体家族中表达范围最广,识别病原微生物种类最多的成员。它可单独或协同其他Toll样受体家族成员完成对病原体相关分子模式的识别,触发机体对致病微生物的级联免疫应答,尤其是针对细胞毒素的抗炎症反应具有重要的作用,已经成为多种疾病治疗的新靶点。文章对哺乳动物TLR2的分布,结构特征,配体识别,信号转导及其生物学功能的最新研究进展进行了综述。
TLRs（Toll like receptors, TLRs）belongs to a pathogen recognition receptors family of the innate immune system, which is very conservative phylogenetically. TLR2（Toll-like receptors 2, TLR2） exists extensively and identifies the maximum multiple pathogens among the cloned TLR family members. TLR2 can recognize pathogens alone or in collaboration with the other TLRs members. It is the initial step in a cascade of events leading to immune responses, especially against the eytotoxin of anti-inflammatory response. Meanwhile it has become a new target for the treatment of a variety of diseases. In this article, we emphasize the research progress in the distribution and structure character, ligand recognition, signal pathway and biological functions of mammals TLR2.
出处
《沈阳师范大学学报（自然科学版）》
CAS
2013年第1期124-128,共5页
Journal of Shenyang Normal University:Natural Science Edition
基金
国家自然科学基金资助项目(30870276)
沈阳师范大学实验中心主任基金资助项目(201-52011005)
