摘要
目的:研究酮洛芬巴布剂的最优处方并考察其影响因素。方法:采用正交试验法设计处方,拉力机测定粘着强度,利用Franz扩散池考察体外经皮渗透性。结果:筛选出最优处方,其粘着强度为40N,稳态流量为9·72μg/(cm2·h)。结论:建立的巴布剂制备工艺合理、稳定,粘着强度和透皮效果为其主要质量影响因素。
OBJECTIVE： To optimize the matrix formulation of ketoprofen cataplasm and to investigate its influencing factors. METHODS： Orthogonal design was used to design formulations,adhesive stress was tested with the tension meter and the per cutem permeability in vitro was studied using the franz diffusion cell. RESULTS： The optimal poultice was acquired with adhesive stress at 40 N and steady permeation flux at 9.72 μg/ （cm^2 · h） . CONCLUSION： The established preparation technique of poultice is stable and feasible, and its leading influencing factors are adhesive stress and transdermal effects.
出处
《中国药房》
CAS
CSCD
北大核心
2006年第11期826-828,共3页
China Pharmacy
关键词
酮洛芬
巴布剂
正交试验
粘着强度
稳态流量
Ketoprofen
Poultice
Orthogonal test
Adhesive stress
Steady permeation flux
