摘要
目的:制备布洛芬二元醇脂质体并对其进行体外评价。方法:采用注入法制备布洛芬二元醇脂质体,以包封率为指标优化处方中乙醇与丙二醇比例;采用Franz扩散池进行离体皮肤渗透试验,测定布洛芬在接收液内的累积渗透量及皮内滞留量。结果:乙醇与丙二醇比例为7∶3时制得的布洛芬二元醇脂质体包封率最高(73.6±1.4)%,其透过皮肤进入接收液中的累积渗透量为乙醇脂质体的1.82倍。二元醇脂质体[乙醇-丙二醇(7∶3)]和乙醇脂质体24 h皮肤中药物滞留量分别为43.67±2.11和38.02±1.44。结论:二元醇脂质体可有效提高布洛芬的皮肤渗透量及皮内滞留量。
OBJECTIVE To prepare and evaluate ibuprofen binary ethosomes. METHODS Ethanol infusing method was used to prepare ibuprofen binary ethosomes. The retention of drug in mice skin and accumulation in vitro percutaneous permeability of ibupro- fen was determined by Franz diffusion cells. RESULTS The encapsulation efficiency of ibuprofen binary ethosomes （ethanol/propylene glycol = 7：3） was （73. 6 ± 1. 4）%. The percentage of ibuprofen in binary ethosomes permeated from isolated skin was increased 1.82 times than that of ethosomes. The retention amount of binary ethosomes （ethanol/propylene glycol = 7：3） and ethosomes was 43. 67 ± 2. 11 and 38. （12 ± 1.44 in the skin after 24 h. CONCLUSION Binary ethosomes can significantly improve the permeation of ibuprofen through mice skin and increase the accumulation of drug in mice skin.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2012年第14期1111-1114,共4页
Chinese Journal of Hospital Pharmacy
关键词
布洛芬
二元醇脂质体
透皮吸收
ibuprofen
binary ethosomes
transdermal penetration
