新生儿缺氧缺血性脑病脑脊液中TNF-α及IL-6水平的变化及意义被引量：7

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摘要目的:探讨新生儿缺氧缺血性脑病(HIE)患儿急性期与恢复期脑脊液中TNF-α和IL-6水平的变化及其临床意义。方法:31例HIE患儿分为轻、中、重度HIE组,以同期收治的无窒息病史新生儿8例为对照组,分别于HIE急性期(出生后24h内)和恢复期(出生后第5天)测定患儿脑脊液中TNF-α和IL-6的水平。比较各组间的差异。结果:急性期时,中、重度HIE组脑脊液中的TNF-α水平高于轻度HIE组和对照组。3组HIE患儿IL-6水平均高于对照组。恢复期时,轻度HIE组TNF-α水平无明显变化,而中、重度HIE组则继续升高。IL-6水平在轻、中度HIE组明显下降,但重度HIE组没有明显变化。结论:脑脊液中TNF-α和IL-6水平的动态变化反映了HIE的发生发展过程,与HIE病程密切相关,有助于HIE早期病情的评估。

作者余连芝赖伟权唐建平余曼玲

机构地区广东省河源市人民医院儿科广州市增城区妇幼保健院

出处《实用医学杂志》 CAS 2006年第11期1272-1273,共2页 The Journal of Practical Medicine

关键词缺氧缺血脑新生儿肿瘤坏死因子白细胞介素6

分类号 R722.1 [医药卫生—儿科]

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