摘要
目的探讨新生儿缺氧缺血性脑病(HIE)血清白介素(IL)1β和IL18的变化以及二者与HIE临床分度之间的关系。方法采用酶联免疫吸附法(ELISA)检测了70例HIE患儿(按临床分度分轻、中、重三组)及22例正常对照组足月新生儿第三天血清IL1β和IL18的水平。结果(1)HIE组新生儿血清IL1β和IL18均明显高于对照组(P<0.05);(2)与正常对照组比较,中、重度HIE组血清IL1β和IL18水平明显增高(P<0.01);轻度HIE组血清IL1β、IL18水平则与正常对照组无显著性差异(P>0.05)。HIE组间血清IL1β及IL18两两比较,中度与轻度组比较有显著性差异(P<0.05);重度组与其他两组比较均明显升高(P<0.01)。结论急性期HIE患儿血清IL1β和IL18水平与HIE临床分度基本一致。因此,血清IL1β和IL18水平可作为辅助诊断HIE的指标,对协助HIE临床分度具有重要价值。
Objective To explore the changes of serum IL-1β and IL-18 of newborns with hypoxic-ischemic encephalopathy （HIE） and the correlation between IL-1β, IL-18 and the stage of HIE. Methods Serum IL-1β and IL-18 of infants with HIE and control subjects were measured by enzyme-linked immunosurbent assay （ELISA）. Results （1）Serum concentrations of IL-1β and IL-18 of infants with HIE were significantly higher than those in control subjects respectively（ P〈0.05）. （2） Serum concentrations of IL-1β and IL-18 of infants with HIE of stage 2 or stage 3 were higher significantly than those of control subjects（P〈0.01）. There was no difference between infants with HIE of stage 1 and control subjects（ P〉0.05 ）. Infants with HIE of stage 2 had significantly higher serum IL-1β and IL-18 levels than infants with HIE of stage 1（P〈0.05）. Infants with stage 3 had significantly higher serum IL-1β and IL-18 levels than other two HIE groups（P〈0.01）.Conclusion Our findings suggest that serum concentrations of IL-1 and IL-18 are assistant markers for early estimates of HIE and have great value in judging the stage of HIE correctly.
出处
《小儿急救医学》
CAS
2005年第4期264-266,共3页
Pediatric Emergency Medicine
