摘要
目的 研究新生儿缺氧缺血性脑病(HIE)极期和恢复初期血清可溶性细胞间黏附分子-1(sICAM-1)水平变化及其在HIE发病机制中的意义。方法 以17例正常足月新生儿脐血为对照组,对36例HIE患儿极期、恢复初期血清sICAM-1水平进行观察。血清sICAM-1水平采用双抗体夹心酶联免疫(ELISA)法检测。统计学处理采用方差分析、q检验。结果 HIE患儿36例极期血清sICAM-1[(216.64±85.32)μg／L]较对照组[(6.16±4.05)μg／L]显著升高(q=17.41 P<0.001);恢复初期血清sICAM-1水平[(78.44±31.68)μg／L]较极期显著下降(q=14.27 P<0.001),但仍显著高于对照组(q=5.98 P<0.001)。结论 HIE极期血清sIC-MA-1水平急剧升高。ICAM-1参与HIE脑损伤的病理过程。
Objective To study the changes of soluble intercelluar adhesion molecule-1 (sICAM-1) in serum of neonates with hy-poxic-ischemic encephalopathy (HIE),and significance of changes of serum sICAM-1 in HIE pathogenesis. Methods There were 17 controls of neonates and their sICAM-1 concentrations in serum were detected with enzyme-linked immunosorbent assay (ELISA) at the critical stage and at the beginning of convalescent stage in 36 cases of HIE neonates and 17 normal neonates. The data were analyzed with analysis of variance, Newman-Keuls q test. Results The concentrations of sICAM-l[(216.64±85.32)μg/L] at the critical stage of 36 cases HIE neonates were significantly higher than those [(6. 16±4.05) μg/L ] of control group (q = 17. 42 P < 0.001). The concentration of sICAM-1[(78.44 ±31.68)μg/L]at the beginning of convalescent stage was significantly lower than that at the critical stage(q = 14.27 P<0.001).But it was significantly higher than that in control group (q = 5.98 P<0.001).Conclusions The sICAM-1 concentration rises sharply at the critical stage of HIE, which suggests the sICAM-1 may play an important role in the brain damage of HIE pathological process.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2004年第10期830-832,共3页
Journal of Applied Clinical Pediatrics
关键词
婴儿
新生
脑缺氧
脑缺血
可溶性细胞间黏附分子-1
血清
neonate
hypoxic-ischemic encephalopathy
soluble intercelluar adhesion molecule-1
serum
