摘要
目的了解市售牙膏常中用抗生素的种类和含量。方法从超市选购标注对口腔疾病有不同预防和治疗作用的10种牙膏,先用纸片扩散法初步筛选出可能含有抗生素的牙膏,再用液相色谱法检测抗生素的种类和含量。结果在所检的10种牙膏中,1种牙膏检出诺氟沙星,基质量分数达0.06%;2种牙膏检出甲硝唑,其质量分数分别为0.01%和0.37%;10种牙膏均未检出替硝唑。结论市售的部分牙膏中含有常用抗生素。
Objective To understand the kinds and content of antibiotic used in the toothpaste selling in China. Methods 10 kinds of toothpaste samples labelled to be able to prevent and/or cure some oral diseases were collected from the supermarkets, the contents of antibiotic were determined by HPLC after selected by disk diffusion susceptibility test. Results Norfloxacin was detected in one kind of toothpaste collected from several supermarkets, the content was 0.06%. Metronidazole was detected in two kinds of toothpaste, the contents were 0.01% and 0.37% respectively, no tinidazole was detected in all samples. Conclusion Some antibiotic in common use have been detected in some toothpaste sold in supermarkets in China.
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2006年第3期244-246,共3页
Journal of Environment and Health
基金
河南省科教发展计划资助项目(991170408)
关键词
牙膏
色谱法
液相
抗生素
Toothpaste
Chromatography, liquid
Antibiotic
