摘要
目的观察脉络膜黑色素瘤的组织病理学特征。方法回顾分析64例病理确诊的脉络膜黑色素瘤病理资料。按照美国眼黑色素瘤多中心研究组的测量方法和WHO的分类标准,测量和观察大体标本中的肿瘤大小和光学显微镜下的肿瘤细胞学类型;以肿瘤前缘累及部位对肿瘤所处位置进行分类;以肿瘤细胞向外浸润程度对肿瘤蔓延程度进行分级。结果64例脉络膜黑色素瘤中,大肿瘤25例,占39.1%;中等大小肿瘤31例,占48.4%;小肿瘤8例,占12.5%。梭形细胞型42例,占65.6%,其中,梭形细胞A型15例,占23.4%,梭形细胞B型27例,占42.3%;上皮样细胞型7例,占10.9%;混合型10例,占15.6%;其它型5例,占7.8%。肿瘤细胞未累及巩膜者25例,占39.1%;累及巩膜但限于巩膜层内者22例,占34.4%;穿透巩膜全层达眼球表面者12例,占18.7%;眶内浸润者5例,占7.8%。结论脉络膜黑色素瘤组织病理学特征变化多样,临床上以梭形细胞型最常见,易伴巩膜浸润。
Objective To investigate the histopathological characteristics of choroidal melanoma. Methods The histopathological data from 64 patients with choroidal melanoma were analyzed retrospectively. The tumor size and the cytological types were observed and detected. The locations of the tumor were classified according to the involved part invaded by the anterior margine of the tumor, and the degrees of the development of the tumor were graded according to the extent of the outward infiltration of the tumor cells. Results In 64 patients with choroidal melanoma, There were large, medium, and small tumors in 25（39. 1% ）, 31（48.4% ）, and 8（12.5% ） respectively. The spindle cell type was found in 42 patients （65.6%） including spindle cell A and B type in 15 （23.4%） and 27 （42.3%） respectively; epithelioid and mixed cell type was found in 7（10.9% ） and 10（15.6% ） respectively; the other types were found in 5（7.8% ）. Twenty-five cases（39.1% ）had no invasion with sclera, 22（34.4% ）had but limited to sclera, 12（18.8%）penetrated through sclera and 5（7.8%）had intra-orbit infiltration. Conclusion The histopathological characteristics of choroidal melanoma are multiple, and spindle cell type is the most common one. The choroidal melanoma can easily invade the sclera.
出处
《中华眼底病杂志》
CAS
CSCD
北大核心
2006年第3期161-165,共5页
Chinese Journal of Ocular Fundus Diseases
