摘要
观察了二硫化碳（ＣＳ２）腹腔注射染毒对大鼠肝脏脂质过氧化物（ＬＰＯ）含量超氧化物歧化酶（ＳＯＤ）和谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）活力的影响，急性染毒实验结果显示，大鼠肝ＬＰＯ含量随ＣＳ２染毒剂量增加而明显升高（ｒ＝０．８１０８，Ｐ＜０．０１），ＳＯＤ活性随剂量增加有降低趋势，ＧＳＨ－ＰＸ活性未见显著变化。亚急性实验结果显示，染毒２１ｄ染毒组ＧＳＨ－ＰＸ活力，染毒４５ｄ染毒组ＳＯＤ及ＧＳＨ－ＰＸ活力与对照组比较均显著降低（Ｐ＜０．０５），这表明，ＣＳ２是一个重要的致脂质过氧化物。
The paper reported the effect of intraabdominal injection CS2 on amount of Lipidperoxides(LPO)and the activity of Superoxide dismutase(SOD)and Glutathione peroxidase(GSH Px)in rat liver.The result of the acute toxicity experiment indicated that the amount of LPO increased(r= 0. 8108, P<0. 01)and activity of SOD decreased with the rise of CS2 dosage.There's little change on the acticity of GSH-Px, The result of subacute toxicity experiment inicated that for the poisoning group the activity of GSH-Px after 21 days,and the activity of SOD and GSH-Px after 45 days all decreased significantly(P<0.05)compared with that of control group. All those showed that CS2 was an important substance to produce Lipidperoxides.
出处
《实用预防医学》
CAS
1996年第1期36-37,共2页
Practical Preventive Medicine
关键词
二硫化碳
脂质过氧化物
肝脏毒性
carbon disculfide Lipidperoxide superoxide dismutase Glutathion perOxidase liver toxcity
