摘要
在缺氧和高碳酸条件下测定肺、脑动脉对乙酰胆碱（Ａｃｈ）、硝普钠（ＳＮＰ）、硝酸甘油（ＮＴＧ）的反应性（ＥＣ＿（５０）），以研究其生成一氧化氮（ＮＯ）及对ＮＯ反应的改变。结果：缺氧和高碳酸都降低肺动脉对ＳＮＰ、ＮＴＧ、Ａｃｈ的反应性，缺氧提高脑动脉对ＳＮＰ、ＮＴＧ的反应性，而高碳酸降低其对ＳＮＰ的反应性；提示缺氧可能降低肺动脉对ＮＯ的反应性并抑制Ａｃｈ诱发其内皮细胞产生ＮＯ，但提高脑动脉对ＮＯ反应性，而不影响Ａｃｈ诱导其内皮产生ＮＯ；高碳酸则抑制二者对ＮＯ的反应性，但抑制Ａｃｈ诱发肺动脉内皮产生ＮＯ而不影响Ａｃｈ诱发脑动脉内皮产生ＮＯ。
In this study,the reactivity of pulmonary and cerebral arteries to acetylcholine(Ach),sodium nitroprusside(SNP)and nitroglycerin(NTG)under hypoxia and hypercapnia was determined to investigate the changes in the production of NO and the reactivity to NO. The results showed that hypoxia and hypercapnia could decrease the reactivity of pulmonary arteries to SNP,NTG and Ach.Hypoxia could enhance the reactivity of cerebral arteries to SNP and NTG,while hypercapnia could decrease their reactivity to SNP.This study suggests that hypoxia decrease;the reactivity of pulmonary arteries to NO and the production of Ach-induced NO,but increases the reactivity of cerebral arteries to NO without significant change in the production of Ach-induced NO.Hypercapnia inhibits the reactivity of both pulmonary and cerebral arteries to NO.It may also inhibit the production of Achinduced NO in pulmonary arteries but not in cerebral arteries.
出处
《同济医科大学学报》
CSCD
北大核心
1996年第2期92-95,共4页
Acta Universitatis Medicinae Tongji
基金
国家自然科学基金
关键词
缺氧症
高碳酸
一氧化氮
肺动脉
脑动脉
hypoxia
hypercapnia
nitric oxide
pulmonary artery
cerebral artery
