摘要
采用聚乙烯吡咯烷酮(PVP-K30)作为载体,用溶剂法制备乌索酸(UA)固体分散体,以提高制剂中UA的溶出度;建立高效液相色谱(HPLC)法测定固体分散体的体外溶出度,并进行红外和紫外光谱分析,鉴别药物在载体中的存在状态.研究结果表明,HPLC法测定UA的溶出度准确可靠、稳定、无载体的干扰;选择PVP-K30作为载体制备成固体分散体,能显著地提高UA的体外溶出速度.
To enhance the dissolution rate of ursolie acid （UA） from its preparation, solid dispersion systems of UA in PVP-K30 were prepared at various weight ratios by co-evaporation of drug and PVP-K30 ethanoi solution. The HPLC method were established to measure its external dissolusion rate. IR and UV spectral analysis were used to describe the status of drug in carriers. The result shows that HPLC method is accurate and reliiable, and no interference occurs from carriers. The solid dispersion system in PVP-K30 can improve well the dissolution rate of ursolic acid.
出处
《江西师范大学学报（自然科学版）》
CAS
北大核心
2006年第1期81-83,共3页
Journal of Jiangxi Normal University(Natural Science Edition)
基金
国家"863"计划重点资助项目(2002AA2Z3217)
