摘要
目的探讨胃粘膜中S-100阳性细胞(S-100+DC)浸润、增殖细胞核抗原(PCNA)的表达在胃癌发生、发展中的作用及临床意义。方法应用免疫组织化学方法对57例胃癌、18例正常胃粘膜组织中的S-100+DC、PCNA进行检测。结果S-100+DC、PCNA在胃癌组中的表达均显著高于正常胃粘膜组(P<0.05)。在低分化、淋巴结转移阳性和有远处转移胃癌组织中S-100+DC数目明显减少(P<0.01)。PCNA阳性表达率与淋巴结转移、远处转移、分化程度、肿瘤大小密切相关(P<0.05),而与肿瘤浸润深度、临床分期无关(P>0.05)。胃癌组织中S-100+DC与PCNA的表达呈负相关性。结论胃粘膜微环境中S-100+DC与PCNA的变化与胃癌临床病理参数密切相关。胃癌组织内S-100+DC增多可抑制肿瘤细胞的增殖潜力,并具有抗肿瘤转移的作用。
cells （ S - 100 Objective ^＋ DC） and To study the clinical significance and effects of the expression of S - 100^ ＋ dendritic proliferating cell nuclear antigen（PCNA） in the occurrence and development of gastric carcinoma. Methods S - 100 ^＋ DC and PCNA expression was detected in 43 specimens of gastric carcinoma,24 cases of normal gastric mucosa using immunohistochemistry. Results The expression of S - 100 ^＋ DC and PCNA in gastric carcinoma was markly higher than in normal gastric mucosa （ P 〈 0.05）. The number of S -100^ ＋ DC in the gastric carcinoma tissues withlow differentiation, lymph node and distant metastasis was significantly lower （ P 〈 0.01 ）. The positive rates of PCNA were correlated with lymph node metastasis, diatant metastasis, degree of differentiation, tumor size （ P 〈 0.05 ）, and no relation with depth of invasion and clinical stage （ P 〉 0.05 ）. A negative relationship was found between S - 100 ^＋ DC and PCNA expressions in gastric cancer. Conclusion The change of S - 100 ^＋ DC and HLA - DR in gastric mucosa were closely correlated with the clinical pathological parameters of gastric carcinoma. S - 100 ^＋ DC in gastric cancer might play a role in inhibiting the growth of tumor cells and anti - tumor metastasis.
出处
《中原医刊》
2006年第6期1-3,共3页
Central Plains Medical Journal
关键词
树突状细胞
增殖细胞核抗原
胃癌
免疫组织化学
Dendritic cells
Proliferating cell nuclear antigen
Gastric carcinoma
Immunohistochemistry
