摘要
目的探讨胃癌组织中S-100蛋白的表达在胃癌发生、发展、预后以及治疗中的临床意义。方法应用免疫组织化学方法对51例胃癌标本、17例正常胃黏膜标本中的S-100阳性细胞(S-100+DC)进行检测。结果 S-100+DC在胃癌组中的表达显著高于正常胃黏膜组(P<0.05)。S-100+DC的表达率与分化程度、淋巴结转移、远处转移密切相关(P<0.05),而与肿瘤的大小、浸润深度无关(P>0.05)。结论胃癌微环境中S-100+DC的表达与胃癌的临床病理参数密切相关。S-l00蛋白的表达水平可评价DC在肿瘤组织中的浸润程度,以此可观察肿瘤患者机体的免疫状态,估计肿瘤的转移、预后等情况。
Purpose To study the clinical significance of the expression of S-100 protein in the occur- rence,development,prognosis and treatment of the gastric carcinoma. Methods S-100 positive cells （S- 100 ＋ DC） were detected in 51 specimens of gastric carcinoma and 17 specimens of normal gastric muco- sa using immunohistochemical method. Results The expression of S-100 ＋ DC in gastric carcinoma was obviously higher than that in normal gastric mucosa（P 〈 0.05 ）. The positive rates of S-100 ＋ DC were correlated with the degree of differentiation,lymph node metastasis and distant metastasis（P 〈 0.05 ）, and irrelevant with the tumor size and depth of invasion（P 〉 0.05 ）. Conclusion The expression of S-100 ＋ DC in the micro environment of gastric carcinoma was closely correlated with the clinical pathological pa- rameters. The expression level of S-100 protein can estimate the infiltration of DC in gastric carcinoma ti- ussue. By force of that we can observe the immune state of tumor patients and estimate the situation of tumor＇s metastasis and prognosis.
出处
《中国生化药物杂志》
CAS
CSCD
北大核心
2012年第5期643-645,共3页
Chinese Journal of Biochemical Pharmaceutics
