摘要
为探讨Ｓ－１００蛋白阳性树状细胞（Ｓ－１００ｐｒｏｔｅｉｎｐｏｓｉｔｉｖｅｄｅｎｄｒｉｔｉｃｃｅｌｓ，Ｓ－１００＋ＤＣ）在口腔鳞癌的作用及其临床意义，我们采用卵白素－生物素复合物法染色技术，对６０例口腔鳞癌组织Ｓ－１００＋ＤＣ进行了检测和半定量分析。结果显示，口腔鳞癌高分化组的Ｓ－１００＋ＤＣ密度较中、低分化组及对照组明显增高，经统计学分析，差异有显著性（Ｐ＜０．０５）。原发癌灶内的Ｓ－１００＋ＤＣ密度和局部淋巴结癌转移与否无相关性（Ｐ＞０．０５），但淋巴结内Ｓ－１００＋ＤＣ密度低者较易发生癌转移（Ｐ＜０．０５）。我们认为，Ｓ－１００＋ＤＣ分布可作为判定口腔鳞癌预后及病理组织学分级的参考指标。
The purpose of this study is to investigate the role and clinical significance of S 100 +DC in oral squamous cell carcinoma. Distribution of S 100 +DC in the tumor tissues and regional lymph nodes (LN) of 60 patients with oral squamous cell carcinoma was detected by immunohistochemistry (ABC). The results showed that the S 100 +DC density in tumor tissues was correlated with the tumor histologic grade ( P <0.05). The density of S 100 +DC was significantly higher in regional LN without tumor than those with metastases ( P <0.05). However, there was no difference of S 100 +DC in tumor tissues between patients with and without regional LN metastases. The distribution of S 100 +DC in tumor tissues and regional LN could be considered as a reference indicator of tumor histologic grade and clinical prognosis of patients.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
1997年第3期174-176,共3页
Chinese Journal of Stomatology
关键词
口腔肿瘤
鳞状细胞癌
树状细胞
免疫组织化学
S 100 protein Dendritic cell Oral squamous cell carcinoma Immunohistochemistry
