摘要
目的探讨检测膀胱移行细胞癌(BTCC)组织中微血管密度(MVD)的临床意义。方法应用免疫组织化学LDP法检测61例BTCC,10例正常膀胱组织的MVD。结合临床病理资料进行分析和评价。结果①BTCC组织中MVD明显比正常膀胱组织高(P<0.01);②浸润型BTCC组MVD明显高于浅表型BTCC组(P<0.01);③肿瘤分化越差MVD值越高(P<0.01);④高MVD组较低MVD组复发率高(P<0.01)。结论MVD与BTCC组织学分级、临床分期和预后密切相关,是BTCC细胞生物学行为的一种较理想的标志物。
Objective To investigate the clinical significances of tumour microvessel density （MVD） in bladder transitional cell carcinoma （BTCC）. Methods lmmunohistochemistry （LDP method） was used to study tumor MVD in 61 tissues of primary bladder transitional cell carcinoma and 10 tissues of normal mucosa of bladder. The MVD was analysed with the clinic pathological characters of BTCC. Results ~ The MVD value in tissues of BTCC was significantly higher than that in normal bladder （P〈0.01）. （2） The MVD value in tumors with muscular infiltration was significantly higher than in those without muscular infiltration（P〈0.01）. （3） The less bladder carcinoma differentiated, the higher its MVD（P〈0.01）. （4） The recurrent rate was higher in the group of high MVD （P〈0.01）. different stages, grades, and recurrence rate of BTCC; therefore, Conclusion The MVD values are closely related to the it is a good prognostic marker
出处
《现代泌尿外科杂志》
CAS
2006年第2期81-82,共2页
Journal of Modern Urology
关键词
膀胱肿瘤
癌
免疫组化
微血管密度
bladder neoplasma
carcinoma
immunohistochemistry
microvessel density
