摘要
目的 :探讨膀胱移行细胞癌 (BTCC)微血管密度 (MVD)测定的临床意义。方法 :应用免疫组化二步法 ,检测 10例正常膀胱粘膜、50例BTCC组织的MVD ,结合临床病理资料进行分析和评价。结果 :① 10例正常膀胱粘膜MVD 0 .6～ 1.6个 高倍视野 ,平均值 1.2 0± 0 .3 5,50例BTCC组织的MVD为 4.4～ 13 .4个 高倍视野 ,平均值 8.94± 2 .0 8(P <0 .0 1)。②浸润型肿瘤组较表浅型肿瘤组MVD高 (P <0 .0 1) ,G2和G3级肿瘤组较G1级肿瘤组MVD高 (P <0 .0 1) ,高MVD组较低MVD组复发率高 (P <0 .0 5)。结论 :①BTCC组织较正常膀胱粘膜MVD高 ,差异非常显著。②MVD与BTCC分期、细胞的分级、复发相关 ,MVD为较理想的BTCC细胞生物学行为的标志物 。
Objective: To investigate the clinical significa nces of microvessel d ensity(MVD) in transitional cell carcinoma of the bladder(BTCC). Method s: Immunohistochemistry(two step method) was used to detect the expres s ion of factor Ⅷ re lated antigen (FⅧ-RAg) in 10 tissues of normal mucosa of bladder and in 50 ti s sues of primary transitional cell carcinoma of bladder.The MVD was analysed with the clinic pathological characters of BTCC. Results: ①In 10 tissues of normal mu cosa of bladder, the average MVD value was 1.20±0.35(range 0.6 to 1.6),In 5 0 ti ssues of BTCC, the average MVD Value was 8.94±2.08(range 4.4 to 13.4) ( P <0. 01). ②The average MVD Value was higher in the group of invasive stage( P <0.01)an d higher grades(G2 and G3) ( P <0.01), The recurrent rate was higher in the gr oup of high MVD( P <0.05). Conclusion: ①The MVD value has significan t differences between the tissues of normal bladder mucosa and BTCC. ②The MVD value has correlation t o different stages (according to UICC-TNM ), different grades (according to WHO ), and recurrence,therefore,it has prognostic value.
出处
《江苏大学学报（医学版）》
CAS
2003年第5期400-402,共3页
Journal of Jiangsu University：Medicine Edition
关键词
膀胱癌
移行细胞
免疫组化
微血管密度
Bladder carcinoma
Microvascular density
Immunohistochemistry
